Sodium Hydroxide → HCID 11443447, compound

HRID 733610Notes

Reaction equation

HRID 733610 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:38]=[CH:37][C:13]([CH2:14][N:15]([C:24]3[CH:36]=[CH:35][C:27]4[O:28]C(C)(C)[O:30][C:31](=[O:32])[C:26]=4[CH:25]=3)[C:16](=[O:23])[CH2:17][C:18]3[S:19][CH:20]=[CH:21][CH:22]=3)=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:14][N:15]([C:16](=[O:23])[CH2:17][C:18]3[S:19][CH:20]=[CH:21][CH:22]=3)[C:24]3[CH:36]=[CH:35][C:27]([OH:28])=[C:26]([CH:25]=3)[C:31]([OH:32])=[O:30])=[CH:37][CH:38]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68419912HCID 68419912, compound

Product 1

HCID 11443447HCID 11443447, compound

Procedure

The titled compound was prepared following the procedure C using N-{4-[(4-chlorophenyl)ethynyl]benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)-2-(2-thienyl)acetamide and NaOH as a brown solid (42%). M− (ESI): 499.7; M+ (ESI): 502.3. HPLC, Rt: 4.92 min (Purity: 88.5%).

Sources & evidence

ORD record
ord-a614cd62c725495bae93ec6912bc0726
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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