N-Methyl-D-glucamine → HCID 69050723, compound

HRID 733612Notes

Reaction equation

HRID 733612 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:37]=[CH:36][C:13]([CH2:14][N:15]([C:26](=[O:35])[CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:16]3[CH:17]=[CH:18][C:19]([OH:25])=[C:20]([CH:24]=3)[C:21]([OH:23])=[O:22])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[CH3:38][NH:39][CH2:40][C@@H:41]([C@H:43]([C@@H:45]([C@@H:47]([CH2:49][OH:50])[OH:48])[OH:46])[OH:44])[OH:42]>>[CH3:38][NH:39][CH2:40][C@@H:41]([C@H:43]([C@@H:45]([C@@H:47]([CH2:49][OH:50])[OH:48])[OH:46])[OH:44])[OH:42].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:14][N:15]([C:26](=[O:35])[CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:16]3[CH:17]=[CH:18][C:19]([OH:25])=[C:20]([CH:24]=3)[C:21]([OH:23])=[O:22])=[CH:36][CH:37]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 8567N-Methyl-D-glucamineHCID 57841337HCID 57841337, compound

Product 1

HCID 69050723HCID 69050723, compound

Procedure

The titled compound was prepared following the procedure D using 5-[{4-[(4-chlorophenyl)ethynyl]benzyl}(3-phenylpropanoyl)amino]-2-hydroxybenzoic acid and N-methyl-D-glucamine as a white powder (50%). M− (ESI): 508; M+ (ESI): 509.9. HPLC, Rt: 5.17 min (Purity: 98.2%).

Sources & evidence

ORD record
ord-76bf9d75d17c44139dcadbfd467b05ca
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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