Sodium Hydroxide → HCID 11239480, compound

HRID 733614Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:40]=[CH:39][C:13]([CH2:14][N:15]([C:26]3[CH:38]=[CH:37][C:29]4[O:30]C(C)(C)[O:32][C:33](=[O:34])[C:28]=4[CH:27]=3)[C:16](=[O:25])[C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=3)=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:14][N:15]([C:16](=[O:25])[C:17]3[CH:18]=[CH:19][C:20]([O:23][CH3:24])=[CH:21][CH:22]=3)[C:26]3[CH:38]=[CH:37][C:29]([OH:30])=[C:28]([CH:27]=3)[C:33]([OH:34])=[O:32])=[CH:39][CH:40]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 57841376HCID 57841376, compound

Product 1

HCID 11239480HCID 11239480, compound

Procedure

The titled compound was prepared following the procedure C using N-{4-[(4-chlorophenyl)ethynyl]benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)-4-methoxybenzamide and NaOH as a white powder (45%). 1H NMR (MeOD, 300 MHz) δ 7.53-7.42 (m, 5H), 7.41-7.28 (m, 6H), 7.09 (m, 1H), 6.77 (m, 3H), 5.11 (s, 2H), 3.73 (s, 3H). M− (ESI): 510; M+ (ESI): 511.9. HPLC, Rt: 4.89 min (Purity: 97.6%).

Sources & evidence

ORD record: ord-47d6254e28d74066a57f324e482c6cdd
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07589232B2

Reaction notes

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