N-Methyl-D-glucamine → HCID 11181564, compound

HRID 733618Notes

Reaction equation

HRID 733618 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:36]=[CH:35][C:13]([CH2:14][N:15]([C:26](=[O:34])[C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=3)[C:16]3[CH:17]=[CH:18][C:19]([OH:25])=[C:20]([CH:24]=3)[C:21]([OH:23])=[O:22])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[CH3:37][NH:38][CH2:39][C@@H:40]([C@H:42]([C@@H:44]([C@@H:46]([CH2:48][OH:49])[OH:47])[OH:45])[OH:43])[OH:41]>>[CH3:37][NH:38][CH2:39][C@@H:40]([C@H:42]([C@@H:44]([C@@H:46]([CH2:48][OH:49])[OH:47])[OH:45])[OH:43])[OH:41].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:14][N:15]([C:26](=[O:34])[C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=3)[C:16]3[CH:17]=[CH:18][C:19]([OH:25])=[C:20]([CH:24]=3)[C:21]([OH:23])=[O:22])=[CH:35][CH:36]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 8567N-Methyl-D-glucamineHCID 11181565HCID 11181565, compound

Product 1

HCID 11181564HCID 11181564, compound

Procedure

The titled compound was prepared following the procedure D using 5-[{4-[(4-chlorophenyl)ethynyl]benzyl}(3-fluorobenzoyl)amino]-2-hydroxybenzoic acid and N-methyl-D-glucamine as a white powder (37%). M− (ESI): 497.9. HPLC, Rt: 4.93 min (Purity: 99.2%).

Sources & evidence

ORD record
ord-3fe5b643d63c45edbd299b6eae4ec097
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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