反应详情

温度

50 °C

To a solution of 4-(4-benzyloxy-3-cyanoindol-1-yl)benzoic acid ethyl ester (0.16 g) in ethanol (2 mL) was added 2 mol/L aqueous sodium hydroxide solution (0.4 mL), and this mixture was stirred at 50° C. overnight. Ethanol was removed under reduced pressure, and to this reaction mixture was added 2 mol/L hydrochloric acid (3 mL). The precipitated solid was collected by filtration, and this solid was washed with water and n-hexane to give the title compound (0.11 g).

1. customEthanol was removed under reduced pressure
2. additionto this reaction mixture was added 2 mol/L hydrochloric acid (3 mL)
3. filtrationThe precipitated solid was collected by filtration
4. washthis solid was washed with water and n-hexane