N-Methyl-D-glucamine → HCID 11468093, compound

HRID 733620Notes

Reaction equation

HRID 733620 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:35]=[CH:34][C:13]([CH2:14][N:15]([C:26]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)=[O:27])[C:16]3[CH:17]=[CH:18][C:19]([OH:25])=[C:20]([CH:24]=3)[C:21]([OH:23])=[O:22])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[CH3:36][NH:37][CH2:38][C@@H:39]([C@H:41]([C@@H:43]([C@@H:45]([CH2:47][OH:48])[OH:46])[OH:44])[OH:42])[OH:40]>>[CH3:36][NH:37][CH2:38][C@@H:39]([C@H:41]([C@@H:43]([C@@H:45]([CH2:47][OH:48])[OH:46])[OH:44])[OH:42])[OH:40].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:14][N:15]([C:26]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)=[O:27])[C:16]3[CH:17]=[CH:18][C:19]([OH:25])=[C:20]([CH:24]=3)[C:21]([OH:23])=[O:22])=[CH:34][CH:35]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 8567N-Methyl-D-glucamineHCID 11468094HCID 11468094, compound

Product 1

HCID 11468093HCID 11468093, compound

Procedure

The titled compound was prepared following the procedure D using 5-[{4-[(4-chlorophenyl)ethynyl]benzyl}(cyclohexylcarbonyl)amino]-2-hydroxybenzoic acid and N-methyl-D-glucamine as a white powder (36%). M− (ESI): 486.1; M+ (ESI): 488.1. HPLC, Rt: 5.25 min (Purity: 98.8%).

Sources & evidence

ORD record
ord-8cebc75934be4f288a130be64943b973
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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