3-Cyclopentylpropionyl chloride → HCID 57841331, compound

Participants

Reaction Steps

The titled compound was prepared following the procedure B using methyl 8-({4-[(4-fluorophenyl)ethynyl]benzyl}amino)-5,6,7,8-tetrahydro-2-naphthalenecarboxylate and 3-cyclopentylpropionyl chloride as a white powder (80%). 1H NMR (CDCl3, 300 MHz) δ 1.06 (m, 2H), 1.41-2.10 (m, 11H), 2.27-2.60 (m, 2H), 2.77 (m, 2H), 3.87 (s, 3.4H), 4.07 (d, J=17.9 Hz, 0.6H), 4.52 (d, J=18.5 Hz, 0.6H), 4.86 (d, J=15.6 Hz, 0.4H), 5.10 (m, 0.4H), 6.06 (m, 0.6H), 7.00-7.20 (m, 5H), 7.36 (d, J=8.1 Hz, 1H), 7.48 (m, 3H), 7.66 (d, J=10.4 Hz, 1H), 7.78 (m, 1H). HPLC, Rt: 5.83 min (Purity: 99.4%).

Provenance & Evidence