Lithium Hydroxide → HCID 57841397, compound

Participants

Reaction Steps

The titled compound was prepared following the procedure F using methyl 8-((3-cyclopentylpropanoyl){4-[(4-fluorophenyl)ethynyl]benzyl}amino)-5,6,7,8-tetrahydro-2-naphthalenecarboxylate in the presence of LiOH as a white powder (87%). 1H NMR (MeOD, 300 MHz) δ 1.07 (m, 2H), 1.59-2.26 (m, 12H), 2.28 (qt, J=7.6 Hz, 1H), 2.48 (m, 1H), 2.61 (m, 1H), 2.83 (m, 2H), 4.21 (d, J=18.5 Hz, 0.6H), 4.64 (d, J=18.3 Hz, 0.4H), 4.80 (m, 1H), 5.29 (m, 0.4H) 5.95 (m, 0.6H), 7.10 (m, 3H), 7.24 (d, J=8.5 Hz, 2H), 7.38 (d, J=7.9 Hz, 1H), 7.55 (m, 3H), 7.70 (d, J=6.8 Hz, 1H), 7.80 (d, J=6.7 Hz. 1H) M− (ESI): 522.0; M+ (ESI): 524.1

Provenance & Evidence