4-[2-(4-Butylphenyl)ethynyl]benzaldehyde → Methyl 5-({4-[(4-butylphenyl)ethynyl]benzyl}amino)-2-fluorobenzoate

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Reaction Steps

The titled compound was prepared following the procedure A using 4-[(4-butylphenyl)ethynyl]benzaldehyde and methyl 5-amino-2-fluorobenzoate as a white powder (74%). 1HNMR (CDCl3, 300 MHz) δ 7.51 (d, J=7.9 Hz, 2H), 7.45 (d, J=8.0 Hz, 2H), 7.34 (d, J=8.0 Hz, 2H), 7.17 (m, 3H), 6.97 (m, 1H), 6.76 (m, 1H), 4.35 (s, 2H), 3.92 (s, 3H), 2.63 (t, J=7.8 Hz, 2H), 1.61 (m, 2H), 1.37 (m, 2H), 0.94 (t, J=7.4 Hz, 3H). M+ (ESI): 414.0. HPLC, Rt: 5.78 min (Purity: 98.2%).

Provenance & Evidence