N-Methyl-D-glucamine → HCID 11251033, compound

HRID 733631Notes

Reaction equation

[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:37]=[CH:36][C:16]([CH2:17][N:18]([C:29](=[O:35])[CH2:30][C:31]([CH3:34])([CH3:33])[CH3:32])[C:19]3[CH:20]=[CH:21][C:22]([F:28])=[C:23]([CH:27]=3)[C:24]([OH:26])=[O:25])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[CH3:38][NH:39][CH2:40][C@@H:41]([C@H:43]([C@@H:45]([C@@H:47]([CH2:49][OH:50])[OH:48])[OH:46])[OH:44])[OH:42]>>[CH3:38][NH:39][CH2:40][C@@H:41]([C@H:43]([C@@H:45]([C@@H:47]([CH2:49][OH:50])[OH:48])[OH:46])[OH:44])[OH:42].[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[C:12][C:13]2[CH:37]=[CH:36][C:16]([CH2:17][N:18]([C:29](=[O:35])[CH2:30][C:31]([CH3:33])([CH3:32])[CH3:34])[C:19]3[CH:20]=[CH:21][C:22]([F:28])=[C:23]([CH:27]=3)[C:24]([OH:26])=[O:25])=[CH:15][CH:14]=2)=[CH:9][CH:10]=1)[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 8567N-Methyl-D-glucamine

HCID 11251034HCID 11251034, compound

Product 1

HCID 11251033HCID 11251033, compound

Procedure

The titled compound was prepared following the procedure D using 5-[{4-[(4-butylphenyl)ethynyl]benzyl}(3,3-dimethylbutanoyl)amino]-2-fluorobenzoic acid and N-methyl-D-glucamine as a white powder (90%). M− (ESI): 498.0; M+ (ESI): 500.4. HPLC, Rt: 5.48 min (Purity: 99.3%).

Sources & evidence

ORD record: ord-7599e65eae084e8bb1c8ef9833a317e0
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07589232B2

Reaction notes

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