3,3-Dimethylbutanoyl chloride → N-{4-[(4-butylphenyl)ethynyl]benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)-3,3-dimethylbutanamide

Participants

Reaction Steps

The titled compound was prepared following the procedure M using 7-({4-[(4-butylphenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one and tert-butyl acetyl chloride as an orange solid (71%). 1HNMR (CDCl3, 300 MHz) δ: 7.91 (d, J=8.3 Hz, 1H), 7.43 (m, 2H), 7.39 (m, 2H), 7.16 (m, 2H), 7.14 (m, 2H), 6.76 (m, 0.5H), 6.73 (m, 0.5H), 6.55 (m, 1H), 4.88 (s, 2H), 2.61 (t, J=7.7 Hz, 2H), 2.09 (s, 2H), 1.71 (s, 6H), 1.67-1.54 (m, 2H), 1.41-1.27 (m, 2H), 1.00 (s, 9H), 0.92 (t, J=7.4 Hz, 3H). HPLC, Rt: 6.02 min, (Purity: 98.9%).

Provenance & Evidence