1-Ethynyl-4-propylbenzene → N-{4-[(4-propylphenyl)ethynyl]benzyl}-3-cyclopentyl-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)propanamide

HRID 733649Notes

Reaction equation

HRID 733649 reaction equation
Br[C:2]1[CH:31]=[CH:30][C:5]([CH2:6][N:7]([C:17]2[CH:18]=[CH:19][C:20]3[C:25](=[O:26])[O:24][C:23]([CH3:28])([CH3:27])[O:22][C:21]=3[CH:29]=2)[C:8](=[O:16])[CH2:9][CH2:10][CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:4][CH:3]=1.[CH2:32]([C:35]1[CH:40]=[CH:39][C:38]([C:41]#[CH:42])=[CH:37][CH:36]=1)[CH2:33][CH3:34]>>[CH2:32]([C:35]1[CH:36]=[CH:37][C:38]([C:41]#[C:42][C:2]2[CH:31]=[CH:30][C:5]([CH2:6][N:7]([C:17]3[CH:18]=[CH:19][C:20]4[C:25](=[O:26])[O:24][C:23]([CH3:27])([CH3:28])[O:22][C:21]=4[CH:29]=3)[C:8](=[O:16])[CH2:9][CH2:10][CH:11]3[CH2:12][CH2:13][CH2:14][CH2:15]3)=[CH:4][CH:3]=2)=[CH:39][CH:40]=1)[CH2:33][CH3:34]

Participants

3

Reactant 2

HCID 27751331-Ethynyl-4-propylbenzeneHCID 57841396N-(4-bromobenzyl)-3-cyclopentyl-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)propanamide

Product 1

HCID 57841367N-{4-[(4-propylphenyl)ethynyl]benzyl}-3-cyclopentyl-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)propanamide

Procedure

The titled compound was prepared following the procedure N using N-(4-bromobenzyl)-3-cyclopentyl-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)propanamide and 4-propylphenylacetylene as a white powder (40%). M+ (ESI): 550.1. HPLC, Rt: 6.33 min (Purity: 100%).

Sources & evidence

ORD record
ord-25ce26711e7c4618a368fc46a1b3c7cb
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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