N-Methyl-D-glucamine → HCID 11216226, compound

HRID 733651Notes

Reaction equation

HRID 733651 reaction equation
[CH:1]1([CH2:6][CH2:7][C:8]([N:10]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]#[C:29][CH2:30][CH2:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[CH:24][CH:23]=2)[C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[C:13]([OH:20])[CH:12]=2)=[O:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:39][NH:40][CH2:41][C@@H:42]([C@H:44]([C@@H:46]([C@@H:48]([CH2:50][OH:51])[OH:49])[OH:47])[OH:45])[OH:43]>>[CH3:39][NH:40][CH2:41][C@@H:42]([C@H:44]([C@@H:46]([C@@H:48]([CH2:50][OH:51])[OH:49])[OH:47])[OH:45])[OH:43].[CH:1]1([CH2:6][CH2:7][C:8]([N:10]([CH2:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]#[C:29][CH2:30][CH2:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[CH:26][CH:27]=2)[C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[C:13]([OH:20])[CH:12]=2)=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 8567N-Methyl-D-glucamineHCID 11216227HCID 11216227, compound

Product 1

HCID 11216226HCID 11216226, compound

Procedure

The titled compound was prepared following the procedure D using 4-{(3-cyclopentylpropanoyl)[4-(5-phenylpent-1-yn-1-yl)benzyl]amino}-2-hydroxybenzoic acid and N-methyl-D-glucamine as a beige powder (86%). M− (ESI): 508.3. M+ (ESI): 510.4. HPLC, Rt: 5.57 min (Purity: 98.8%).

Sources & evidence

ORD record
ord-1c815e591b5540979ebfdb5def19be62
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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