Ethylmorpholine → HCID 11689242, compound

Participants

Reaction Steps

To a solution of 7-(3-chloro-phenylamino)-3-methyl-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid (34 mg) in dimethylformamide (2 ml) was added 4-ethylmorpholine (57 μl), morpholine (19 μl), 1-hydroxybenzotriazole hydrate (24 mg) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (26 mg) and the solution stirred at room temperature overnight. The dimethylformamide was evaporated and the residue triturated with 5% sodium bicarbonate to give an off white solid. The solid was filtered, washed thoroughly with water, and dried over sodium hydroxide at 50° C. to afford 1-[7-(3-chloro-phenylamino)-3-methyl-1H-pyrrolo[2,3-c]pyridin-4-yl]-1-morpholin-4-yl-methanone (22 mg).

Provenance & Evidence