Morpholine → 1-(7-Chloro-1H-pyrrolo[2,3-c]pyridin-4-yl)-1-morpholin-4-yl-methanone

HRID 733666Notes

Reaction equation

HRID 733666 reaction equation
[Cl:1][C:2]1[C:7]2[NH:8][CH:9]=[CH:10][C:6]=2[C:5]([C:11]([OH:13])=O)=[CH:4][N:3]=1.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[O:13])=[C:6]2[CH:10]=[CH:9][NH:8][C:7]=12

Participants

3

Reactant 2

HCID 8083MorpholineHCID 578408437-chloro-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid

Product 1

HCID 578409141-(7-Chloro-1H-pyrrolo[2,3-c]pyridin-4-yl)-1-morpholin-4-yl-methanone

Procedure

Prepared from 7-chloro-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid in a similar manner to Example 19 (e) using morpholine instead of tetrahydro-pyran-4-ylmethylamine to give the title compound (32 mg).

Sources & evidence

ORD record
ord-51cbb22da8514ee79d10b0b51395c72d
Source dataset
uspto-grants-2009_09
Patent number
US07589206B2

Reaction notes

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