Cyclopropanemethanamine → HCID 57841035, compound

HRID 733673Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[C:12]2[C:13]([Cl:20])=[N:14][CH:15]=[C:16]([C:17]([OH:19])=O)[C:11]=2[C:10]([CH3:21])=[CH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:22]1([CH2:25][NH2:26])[CH2:24][CH2:23]1>>[C:1]([O:5][C:6]([N:8]1[C:12]2=[C:13]([Cl:20])[N:14]=[CH:15][C:16]([C:17](=[O:19])[NH:26][CH2:25][CH:22]3[CH2:24][CH2:23]3)=[C:11]2[C:10]([CH3:21])=[CH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 75646Cyclopropanemethanamine

HCID 44475513HCID 44475513, compound

Product 1

HCID 57841035HCID 57841035, compound

Procedure

Prepared in a similar manner to Example 11 (b) from 7-chloro-3-methyl-pyrrolo[2,3-c]pyridine-1,4-dicarboxylic acid 1-tert-butyl ester using cyclopropylmethylamine (167 μl) instead of morpholine to give the title compound as a pale brown foam (389 mg).

Sources & evidence

ORD record: ord-2449f230449e4171bd58526847ac8553
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07589206B2

Reaction notes

Loading…