Phosphorodichloridic acid, phenyl ester → 5-Bromo-2-chloro-3-nitropyridine

Participants

Reaction Conditions

Reaction Steps

A suspension of 5-bromo-2-hydroxy-3-nitro-pyridine (19.2 g; ex. Maybridge) in phenyl dichlorophosphate (40 ml) was heated at 180° C. for 30 minutes to give a red oil. The reaction mixture was then purified as described in Example 1 Method 1(a) to give the title compound as a pale yellow solid (20.4 g).

Provenance & Evidence