Morpholine → HCID 86760960, compound

HRID 733683Notes

Reaction equation

HRID 733683 reaction equation
C(OC([N:8]1[C:12]2=[C:13]([Cl:26])[N:14]=[CH:15][C:16]([C:17](=[O:25])[NH:18][CH:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[C:11]2[C:10]([CH3:27])=[CH:9]1)=O)(C)(C)C.[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>CO>[ClH:26].[O:22]1[CH2:21][CH2:20][CH:19]([NH:18][C:17]([C:16]2[C:11]3[C:10]([CH3:27])=[CH:9][NH:8][C:12]=3[C:13]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[N:14][CH:15]=2)=[O:25])[CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 57840941HCID 57840941, compound

Product 1

HCID 86760960HCID 86760960, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared in a similar manner to Example 11 (c) from 7-chloro-3-methyl-4-(tetrahydro-pyran-4-ylcarbamoyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester and morpholine (71 mg) except that the hydrochloride salt was formed using methanol instead of dichloromethane as solvent to give the title compound (40 mg).

Workup

  1. customwas formed

Sources & evidence

ORD record
ord-64c00b41815042658cfbb00883ed42ff
Source dataset
uspto-grants-2009_09
Patent number
US07589206B2

Reaction notes

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