3-Chloroaniline → HCID 45487767, compound

Participants

Reaction Steps

A mixture of 4,7-dibromo-1-methyl-1H-pyrrolo[3,2-c]pyridine (290 mg), 3-chloroaniline (153 mg), cesium carbonate (652 mg), tris(dibenzylidineacetone)dipalladium(0) (10 mg) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (6 mg) in dioxan (5 ml) was heated at reflux under nitrogen overnight. A further addition of tris(dibenzylidineacetone)dipalladium(0) (10 mg) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (6 mg) was made and the mixture refluxed for 4 hrs, then a repeat addition made and reflux continued for 2 hrs. The mixture was diluted with ethyl acetate (5 ml), filtered through Celite using ethylacetate and evaporate. The residue was dissolved in ethyl acetate and passed through silica gel eluting with ethyl acetate and evaporated. Purification of the residue by chromatography on Biotage, eluting with isohexane/dichloromethane 1:1, and evaporation gave the title compound (199 mg)

Provenance & Evidence