Diethyl Ether → HCID 44475510, compound

Temperature

110 °C

To a suspension of methyl 4-chloro-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylate (23.1 g) in 1,4-dioxane (300 ml) was added 3-chloroaniline (27 ml). The reaction was heated at 110° C. for 17 hours during which time a solution was rapidly formed upon heating followed by the precipitation of a solid. The reaction was allowed to cool and then partitioned between dichloromethane (700 ml) and saturated sodium carbonate (500 ml). The aqueous layer was separated and further extracted with dichloromethane (300 ml). The organic extracts were combined and dried (MgSO4). This was then combined with another dichloromethane extract of a reaction conducted as above (weight of methyl 4-chloro-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylate is 22.9 g). The solvent was removed to yield an orange/brown solid. This was heated in methanol (650 ml) and 2N sodium hydroxide (350 ml) to 80° C. and stirred for 3 hours. The reaction was cooled and then reduced in vacuo. The residue was stirred with diethyl ether (400 ml) for 15 minutes. The orange liquid was decanted and the solid residue triturated with diethyl ether (400 ml). The solid was filtered then added to water (400 ml). The solution was altered in pH to around 7 with 5N hydrochloric acid. The precipitate was filtered, however was in the form of a sticky gum. All material was transferred into a flask with methanol (>1 L in total). The solution was reduced in vacuo. A precipitate formed after the majority of the methanol had been removed. This was filtered and dried in vacuo to yield the title compound (60.23 g).

1. customwas rapidly formed
2. temperatureupon heating
3. customfollowed by the precipitation of a solid
4. temperatureto cool
5. custompartitioned between dichloromethane (700 ml) and saturated sodium carbonate (500 ml)
6. customThe aqueous layer was separated
7. extractionfurther extracted with dichloromethane (300 ml)
8. dry with materialdried (MgSO4)
9. extractionextract of a reaction
10. customThe solvent was removed
11. customto yield an orange/brown solid
12. temperatureThe reaction was cooled
13. customThe orange liquid was decanted
14. customthe solid residue triturated with diethyl ether (400 ml)
15. filtrationThe solid was filtered
16. additionthen added to water (400 ml)
17. filtrationThe precipitate was filtered
18. customAll material was transferred into a flask with methanol (>1 L in total)
19. customA precipitate formed after the majority of the methanol
20. customhad been removed
21. filtrationThis was filtered
22. customdried in vacuo

ORD record

ord-20179538856b4bcd9d054c98c7ea21d9

Source dataset

uspto-grants-2009_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07589206B2