HRID733694

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7932

3-Chloroaniline

C6H6ClN

结构：Cc1cn(C(=O)OC(C)(C)C)c2c(Cl)ncc(C(=O)N3CCCCC3)c12

HCID57840991

1,1-Dimethylethyl 7-chloro-3-methyl-4-(1-piperidinylcarbonyl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

C19H24ClN3O3

PRODUCTS

生成物

结构：Cc1c[nH]c2c(Nc3cccc(Cl)c3)ncc(C(=O)N3CCCCC3)c12

HCID44475668

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

Prepared in a similar manner to Example 4(d) from 7-chloro-3-methyl-4-(1-piperidin-1-yl-methanoyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester (90 mg) and using 3-chloroaniline (50 ul) instead of 3-bromoaniline and heating for 15 rather than 30 minutes. Isolated by MDAP rather than trituration with diethyl ether to give the title compound (67 mg).

WORKUP

后处理

temperatureheating for 15 rather than 30 minutes