3-Chloroaniline → HCID 57840790, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-chloro-3-methyl-pyrrolo[2,3-c]pyridine-1,4-dicarboxylic acid 1-tert-butyl ester (200 mg) and 3-chloroaniline (0.68 ml) in 1,4-dioxane (3 ml) was heated at 110° C. for 16 hours. The reaction mixture was diluted with EtOAc and basified with 1M NaOH, the aqueous layer was extracted and acidified to pH1 using 1M HCl to afford a precipitate. The precipitate was filtered off and washed with water until neutral. The solid was then sucked dry and dried over sodium hydroxide at 50° C. under vacuum to afford the title compound (197 mg).

Provenance & Evidence