反应详情

4-(3-Chloro-phenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid methyl ester (0.6 g) and 2N sodium hydroxide (2 ml) in methanol were irradiated at 120° C. for 3 minutes with microwaves. The solvent was evaporated and the residue partitioned between ethyl acetate and water. The organic layer washed with dilute citric acid solution and saturated brine solution then dried (MgSO4), filtered and evaporated to yield the title compound as an off-white solid (0.48 g).

1. customThe solvent was evaporated
2. customthe residue partitioned between ethyl acetate and water
3. washThe organic layer washed with dilute citric acid solution and saturated brine solution
4. dry with materialthen dried (MgSO4)
5. filtrationfiltered
6. customevaporated