HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic Acid → 4-[(3-Chloro-phenyl)-methyl-amino]-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | 3-chloro-N-methylaniline | HCID 138900 | — |
| Reactant | Methyl 4-chloro-1-methyl-1H-pyrrolo(3,2-c)pyridine-7-carboxylate | HCID 44475508 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[(3-Chloro-phenyl)-methyl-amino]-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid methyl ester | HCID 57840798 | 47.7% |
Reaction Steps
To a solution of 4-chloro-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid methyl ester (0.5 g) in 1,4-dioxane (5 ml) was added 3-chloro-N-methyl aniline (0.629 g) and methanesulfonic acid (0.289 ml). The mixture was irradiated under microwave conditions at 180° C. for 30 min. 1,4-dioxane was removed in vacuo and the residue purified by MDAP to give the title compound (350 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07589206B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-34764c204a7a45dd94fd0bcfd7e9367b |
| Source note | uspto-grants-2009_09 |