反应详情

To a solution of 4-chloro-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid methyl ester (0.5 g), in methanol (20 ml) was added aqueous 2M sodium hydroxide solution (2 ml) and the mixture was heated to reflux for 4 hours. The methanol was evaporated and the residue was dissolved in water (50 ml) and acidified to pH 1 using aqueous 2M hydrochloric acid. Solid sodium chloride was added to saturated the aqueous phase, the solution was extracted with tetrahydrofuran (2×50 ml). The tetrahydrofuran layers were combined and evaporated to afford the title compound (460 mg).

1. temperaturethe mixture was heated
2. temperatureto reflux for 4 hours
3. customThe methanol was evaporated
4. dissolutionthe residue was dissolved in water (50 ml)
5. additionSolid sodium chloride was added to saturated the aqueous phase
6. extractionthe solution was extracted with tetrahydrofuran (2×50 ml)
7. customevaporated