Ethylmorpholine → HCID 68867151, compound

Participants

Reaction Steps

A solution of 4-[(3-chlorophenyl)amino]-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid (175 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (140 mg), 1-hydroxybenzotriazole hydrate (108 mg), morpholine (106 ul) and N-ethylmorpholine (309 ul) in dimethylformamide (3 ml) was stirred under argon over night. The reaction mixture was diluted with diethyl ether and washed with water. The aqueous layer was acidified with an aqueous 2M hydrochloric acid solution and then extracted three times with diethyl ether. The combined organic layers were washed with brine, dried (MgSO4) and evaporated to afford a brown oil. Purification by MDAP afforded the title compound as a clear oil (86 mg).

Provenance & Evidence