Ammonium Acetate → HCID 68867271, compound

Participants

Reaction Steps

A mixture of methyl 2-[1-formyl-2-(methyloxy)-2-oxoethyl]-1,5-dimethyl-1H-pyrrole-3-carboxylate (2.59 g), ammonium acetate (4.0 g) and methanol (50 ml) was heated under reflux for 4 hours. After cooling the solvent was evaporated and the residue was partitioned between ethyl acetate and water. The aqueous phase was extracted with 2 further portions of ethyl acetate. The combined organic layers were washed with brine, dried (MgSO4) and evaporated to afford the title compound 2.5 g, as a tautomeric mixture.

Provenance & Evidence