Potassium tert-butoxide → HCID 68866324, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 2-{2-amino-1-[(methyloxy)carbonyl]ethenyl}-1,5-dimethyl-1H-pyrrole-3-carboxylate (1.42 g), potassium tert-butoxide (0.13 g) and dimethylformamide (10 ml) was heated under microwave conditions at 160° C. for twenty minutes. The solvent was evaporated and then the residue was suspended in water (20 ml). 2N hydrochloric acid (0.5 ml), then saturated aqueous sodium bicarbonate (1 ml) were added and the mixture stirred for one hour. The solid was collected by filtration, washed with water, then diethyl ether, and dried to afford the title compound 0.789 g.

Provenance & Evidence