5-Aminoindole → N2,N4-bis(indol-5-yl)-5-fluoro-2,4-pyrimidinediamine

HRID 733852Notes

Reaction equation

HRID 733852 reaction equation
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[NH2:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][CH:15]=[CH:14]2>>[NH:16]1[C:17]2[C:13](=[CH:12][C:11]([NH:10][C:2]3[N:7]=[C:6]([NH:10][C:11]4[CH:12]=[C:13]5[C:17](=[CH:18][CH:19]=4)[NH:16][CH:15]=[CH:14]5)[C:5]([F:9])=[CH:4][N:3]=3)=[CH:19][CH:18]=2)[CH:14]=[CH:15]1

Participants

3

Reactant 2

HCID 788675-AminoindoleHCID 2507052,4-Dichloro-5-fluoropyrimidine

Product 1

HCID 22061088N2,N4-bis(indol-5-yl)-5-fluoro-2,4-pyrimidinediamine

Procedure

In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 5-aminoindole were reacted to yield N2,N4-bis(indol-5-yl)-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 20.26 min.; purity: 99%; MS (m/e): 359 (MH+).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c5a385bd88034cfbae3c1102d4b7fb50
Source dataset
uspto-grants-2009_09
Patent number
US07589200B2

Reaction notes

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