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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 733896Generated: October 30, 2026

tert-Butyl bromoacetate → N4-(3-aminophenyl)-N2-(3-tert-butoxycarbonylmethyleneaminophenyl)-5-fluoro-2,4-pyrimidinediamine

https://huagongshe.com/reaction/733896

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl bromoacetateHCID 79177—
ReactantHCID 86600715HCID 86600715—
ReactantHCID 86600716HCID 86600716—
ProductN4-(3-aminophenyl)-N2-(3-tert-butoxycarbonylmethyleneaminophenyl)-5-fluoro-2,4-pyrimidinediamineHCID 22060994—

Reaction Steps

In like manner to the preparation of N2,N4-bis(3-tert-butoxycarbonylmethyleneaminophenyl-5-fluoro-2,4-pyrimidinediamine, N2,N4-bis(3-aminophenyl-5-fluoro-2,4-pyrimidinediamine and tert-butyl bromoacetate were reacted together to give N4-(3-aminophenyl)-N2-(3-tert-butoxycarbonylmethyleneaminophenyl)-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 18.33 min.; purity: 94.5%; MS (m/e): 369.09 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07589200B2
Source datasetuspto-grants-2009_09
ORD IDord-e4cfdb7e5d7840c695af0d02ef9ef1f1
Source noteuspto-grants-2009_09