2-Acetamido-4-methylthiazole-5-sulfonyl chloride → HCID 53492154, compound

HRID 73399Notes

Reaction equation

HRID 73399 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][C:11]=2[F:17])[C:5]([NH2:18])=[CH:4][CH:3]=1.[C:19]([NH:22][C:23]1[S:24][C:25]([S:29](Cl)(=[O:31])=[O:30])=[C:26]([CH3:28])[N:27]=1)(=[O:21])[CH3:20]>>[F:8][C:7]1[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][C:11]=2[F:17])=[C:5]([NH:18][S:29]([C:25]2[S:24][C:23]([NH:22][C:19](=[O:21])[CH3:20])=[N:27][C:26]=2[CH3:28])(=[O:30])=[O:31])[CH:4]=[CH:3][C:2]=1[F:1]

Participants

3

Reactant 2

HCID 969512-Acetamido-4-methylthiazole-5-sulfonyl chlorideHCID 593863065,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine

Product 1

HCID 53492154HCID 53492154, compound

Procedure

According to the general procedure B, 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine (0.182 mmol) was reacted with 2-acetamido-4-methylthiazole-5-sulfonyl chloride (0.5 mmol) to obtain N-(5-(N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)sulfamoyl)-4-methylthiazol-2-yl)acetamide. 1H NMR (CDCl3)) δ 2.1 (s, 3H), 2.2 (s, 3H), 5.9 (dt, 1H), 6.05 (s, 1H), 7.0-7.6 (m, 3H), 7.4 (dd, 1H), 8.0 (s, 1H).

Sources & evidence

ORD record
ord-fc623ec8f60841479a1475e584047827
Source dataset
uspto-grants-2014_09
Patent number
US08829052B2

Reaction notes

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