5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride → HCID 53492156, compound

HRID 73402Notes

Reaction equation

HRID 73402 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][C:11]=2[F:17])[C:5]([NH2:18])=[CH:4][CH:3]=1.[Cl:19][C:20]1[N:24]([CH3:25])[N:23]=[C:22]([CH3:26])[C:21]=1[S:27](Cl)(=[O:29])=[O:28]>>[Cl:19][C:20]1[N:24]([CH3:25])[N:23]=[C:22]([CH3:26])[C:21]=1[S:27]([NH:18][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[C:7]([F:8])[C:6]=1[NH:9][C:10]1[CH:15]=[CH:14][C:13]([I:16])=[CH:12][C:11]=1[F:17])(=[O:28])=[O:29]

Participants

3

Reactant 2

HCID 27771265-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl chlorideHCID 593863065,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine

Product 1

HCID 53492156HCID 53492156, compound

Procedure

According to the general procedure B, 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine (0.182 mmol) was reacted with 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride (0.5 mmol) to obtain 5-chloro-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)-1,3-dimethyl-1H-pyrazole-4-sulfonamide. 1H NMR (300 MHz, CDCl3)) δ 2.1 (s, 3H), 3.6 (s, 3H), 5.8 (s, 1H), 5.95 (dt, 1H), 7.0 (q, 1H), 7.2 (d, 1H), 7.3 (m, 2H), 7.4 (dd, 1H).

Sources & evidence

ORD record
ord-ec934865ef2840d48f643c70ffc0c111
Source dataset
uspto-grants-2014_09
Patent number
US08829052B2

Reaction notes

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