N-methyl-2-pyrrolidone → 2-(4-Nitro-3-methylphenylamino)propane-1,3-diol

Participants

Reaction Conditions

Reaction Steps

2 g of 5-fluoro-2-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.4 g of 2-amino-1,3-propanediol, and 1.57 g of triethylamine. The reaction medium was heated at 60° C. for 10 hours and, after cooling to room temperature, was poured into a water/ice mixture. The resulting medium was extracted with ethyl acetate and the organic phase was then concentrated under vacuum. 1.45 g of 2-(4-nitro-3-methylphenylamino)propane-1,3-diol (11) were obtained.

Provenance & Evidence