Methanol → HCID 21015967, compound

HRID 734198Notes

Reaction equation

HRID 734198 reaction equation
[N:1]1(C(OC(C)(C)C)=O)[CH2:8][C:7]([CH3:10])([CH3:9])[CH2:6][C@H:2]1[C:3]([OH:5])=[O:4].S(Cl)([Cl:20])=O.[CH3:22]O>>[ClH:20].[CH3:22][O:5][C:3](=[O:4])[C@@H:2]1[CH2:6][C:7]([CH3:10])([CH3:9])[CH2:8][NH:1]1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 250673061-(tert-Butoxycarbonyl)-4,4-dimethyl-L-proline

Product 1

HCID 21015967HCID 21015967, compound

Procedure

To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 I, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).

Workup

  1. concentrationThe reaction mixture was concentrated to an amorphous solid (377 mg, 95%)

Sources & evidence

ORD record
ord-adfc53ed842e4000803cd7afd0c114e4
Source dataset
uspto-grants-2009_09
Patent number
US07592316B2

Reaction notes

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