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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 734208Generated: October 30, 2026

Diethyl (ethoxymethylene)malonate → Diethyl 2-(((6-methoxypyridin-3-yl)amino)methylene)malonate

https://huagongshe.com/reaction/734208

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl (ethoxymethylene)malonateHCID 6871—
Reactant6-Methoxy-3-pyridinylamineHCID 81121—
SolventEthanolHCID 702—
ProductDiethyl 2-(((6-methoxypyridin-3-yl)amino)methylene)malonateHCID 619151100.3%

Reaction Steps

A solution of 5-amino-2-methoxypyridine (Aldrich, 100 g, 0.806 mole) and diethyl ethoxymethylenemalonate (Aldrich, 163 mL, 0.806 mole) in EtOH (1 L) was heated at reflux for 4 hours, then was cooled to RT. Concentration to dryness gave the title compound (238 g, quantitative).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07592334B2
Source datasetuspto-grants-2009_09
ORD IDord-060ed770da314cddbeaba45596442696
Source noteuspto-grants-2009_09