Piperazine → 3-(1-Piperazinyl)-1,2-benzisothiazole

Participants

Reaction Conditions

Reaction Steps

A mixture of anhydrous piperazine (2.75 g, 32 mmol) and 3-chloro-benzo[d]isothiazole (1.00 g, 5.80 mmol) were heated in a sealed tube in an oil bath at 125° C. for 24 hours. The orange melt was then quenched with ice water and 50% NaOH was added in one portion. The mixture was extracted with dichloromethane to get the crude product which was purified by recrystallization to afford the title compound as a pale yellow solid in 24% yield (0.260 g). MS (ES+) m/z 220 (M+1).

Provenance & Evidence