1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 11950708, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variation only as required to use 1-(3-trifluoromethylphenyl)piperazine to replace 1-(4-fluorophenyl)-piperazine to react with 6-chloropyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white powder in 57% yield (0.210 g). 1H NMR (300 MHz, CDCl3) δ 8.09 (d, J=9.5 Hz, 1H), 7.98 (t, J=5.4 Hz, 1H), 7.38 (t, J=7.5 Hz, 1H), 7.12 (m, 3H), 7.04 (d, J=9.5 Hz, 1H), 3.96 (m, 4H), 3.55 (m, J=6.72 and 13.2 Hz, 2H), 3.40 (m, 4H), 1.51 (dd, J=6.7 and 13.8 Hz, 2H), 0.74 (m, 1H), 0.45 (m, 2H), 0.08 (m, 2H). 13C NMR (75 MHz, CDCl3) δ 162.9, 150.8, 145.2, 129.8, 127.2, 119.19, 116.75, 112.6, 48.5, 44.7, 39.7, 34.5, 8.7, 4.2.

Provenance & Evidence