Lithium hydroxide, monohydrate → HCID 57843550, compound

Participants

Reaction Steps

A mixture of 1.16 g (2.6 mmol) 2-(3,4-dichloro-phenyl)-4-(1,1-dioxo-hexahydro-1λ6-thia-5,7a-diaza-inden-5-yl)-2-methyl-butyric acid methyl ester and 0.123 g (2.9 mmol) LiOH.H2O in 40 mL water and 40 mL THF was stirred at room temperature for 48 h. After evaporation of THF the pH was adjusted to pH=2 with 2N HCl aq., evaporated to dryness, taken up in acetonitrile and evaporated (3×), The residue was dried at 60° C. under high vacuum and used without further purification in the consecutive amide coupling step. MS(m/e): 421.0 (MH+).

Provenance & Evidence