Isopropyl iodide → HCID 68817055, compound

Participants

Reaction Steps

(S)-1-[1-(tert-Butoxycarbonyl)-piperidine-4-carbonyl]-2-methylpiperazine (D21)(0.13 g), 2-iodopropane (0.08 ml) and potassium carbonate (0.1 g) in acetonitrile (2 ml) were heated at 120° C. in an Emerys Optimiser microwave for 45 min. The mixture was then filtered and evaporated. The crude product was redissolved in DCM (30 ml) and washed with saturated sodium hydrogen carbonate solution (3×20 ml) and brine (20 ml). The organic layer was dried (MgSO4) and evaporated to give the title compound (D22) as a clear oil (0.11 g)

Provenance & Evidence