5-Bromo-2-(trifluoromethyl)pyridine → HCID 68818024, compound

Participants

Reaction Steps

The title compound (E97) was prepared in a similar manner to that described in Example 96, using 5-bromo-2-trifluoromethylpyridine (F. Cottet and M. Schlosser, Eur. J. Org. Chem., 2002, 327-330) and 1-cyclobutyl-4(piperidine-4-carbonyl)-piperazine (free base compound from D7). 1H NMR δ [DMSO-d6]: 1.53-1.83 (6H, m), 2.15 (2H, m), 2.39 (2H, br. m), 2.70 (1H, m), 2.84 (1H, m), 2.96 (3H, m), 3.07 (IH, m), 3.32 (2H, br. m), 3.52-3.68 (2H, m), ca 4.0 (2H, br., partially obscured by H2O signal), 4.22 (1H, br. d, J≈14 Hz), 4.46 (1H, br., J≈14 Hz), 7.44 (IH, dd, J=9, 3 Hz), 7.62 (1H, d, J=9 Hz), 8.43 (1H, d, J=3 Hz), 11.54 (1H, br.); LCMS electrospray (+ve) 411 (MH+).

Provenance & Evidence