4-Chloro-2-pyridinecarbonitrile → HCID 68816753, compound

Participants

Reaction Steps

The title compound (E137) was prepared in a similar manner to that described in Example 98, using 1-cyclobutyl-4-(piperidine-4-carbonyl)-[1,4]-diazepane (D10) and 4-chloro-2-cyanopyridine (T. Sakamoto, S-I. Kaneda, S. Nishimura and H. Yamanaka, Chem. Pharm. Bull., 1985, 33(2), 565-571). 1H NMR δ [DMSO-d6]: 1.51-1.83 (6H, m), 2.01-2.23 (3H, m), 2.37-2.49 (3H, m), 2.72-3.15 (5H, m), 3.30-3.85 (6H, m), 4.01-4.10 (3H, m), 7.14 (1H, dd, J=7, 3 Hz), 7.64 (1H, d, J=3 Hz), 8.26 (1H, d, J=7 Hz), 11.19 and 11.34 (2×br. m, in ˜2:1 ratio, total of 1H); LCMS electrospray (+ve) 368 (MH+).

Provenance & Evidence