2-Fluoro-4-iodoaniline → 3-Ethyl-5,6-difluoro-N-(2-fluoro-4-iodophenyl)-2-nitroaniline

HRID 73436Notes

Reaction equation

HRID 73436 reaction equation
[F:1][C:2]1[CH:8]=[C:7]([I:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH2:10]([C:12]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[C:14](F)[C:13]=1[N+:21]([O-:23])=[O:22])[CH3:11]>>[CH2:10]([C:12]1[C:13]([N+:21]([O-:23])=[O:22])=[C:14]([C:15]([F:19])=[C:16]([F:18])[CH:17]=1)[NH:4][C:3]1[CH:5]=[CH:6][C:7]([I:9])=[CH:8][C:2]=1[F:1])[CH3:11]

Participants

3

Reactant 2

HCID 1856942-Fluoro-4-iodoanilineHCID 593863711-Ethyl-3,4,5-trifluoro-2-nitrobenzene

Product 1

HCID 593863473-Ethyl-5,6-difluoro-N-(2-fluoro-4-iodophenyl)-2-nitroanilineYield 60%

Procedure

2-Fluoro-4-iodoaniline (2.05 g, 10 mmol) and 1-ethyl-3,4,5-trifluoro-2-nitrobenzene (2.37 g, 10 mmol) were reacted using the condition described in example 1 (Step A) to form the title compound (2.47 g, 60%); m/z=407 [M−1]−.

Sources & evidence

ORD record
ord-2c0a72efe5cc4b188a6e0285f9e5dd57
Source dataset
uspto-grants-2014_09
Patent number
US08829052B2

Reaction notes

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