HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-6-(trifluoromethyl)pyridazine → HCID 68816426, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-6-(trifluoromethyl)pyridazine | HCID 28242526 | — |
| Reactant | Methanone, (4-cyclobutyl-1-piperazinyl)-4-piperidinyl-, hydrochloride (1:2) | HCID 68816921 | — |
| Product | HCID 68816426 | HCID 68816426 | — |
Reaction Steps
The title compound (E190) was prepared from 1-cyclobutyl-4-(piperidine-4-carbonyl)-piperazine (free base compound from D7) and 3-chloro-6-trifluoromethyl-pyridazine (A. J. Goodman, S. P. Stanforth and B. Tarbit, Tetrahedron, 1999, 55(52), 15067-15070) using the method described in Example 88. LCMS electrospray (+ve) 398 (MH+). 1H NMR δ [MeOH-d4]: 1.86-2.02 (6H, m), 2.33-2.37 (4H, m), 2.78-2.89 (1H, m), 2.91-3.12 (2H, m), 3.23.3.28 (1H, m), 3.44-3.54 (6H, m), 3.71-3.75 (1H, m), 4.30-4.42 (2H, m), 4.67-4.70 (2×m, 1H), 7.95 (1H, d, J=10 Hz) and 8.00 (1H, d, J=10 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592347B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-900c5e500d624274b3364b0f28834b7a |
| Source note | uspto-grants-2009_09 |