Methylamine → HCID 69069293, compound

Participants

Reaction Steps

The yield was 86%, yellow solid. 1H NMR (500 MHz, CDCl3): δ 1.34 (s, 6H, 2×CH3), 2.29 (s, 3H, CH3), 2.94 (s, 3H, NCH3), 3.52 (s, 1H, NH), 6.5-7.5 (m, 3H, aromatic ring). ESI-MS: 189 (MH+). {2-[Methyl(2,3,3-trimethyl-3H-indol-5-yl)amino]-2-oxoethoxy}-acetic Acid (20) and {2-[Methyl(2-methyl-1,3-benzothiazol-6-yl)-amino]-2-oxoethoxy}acetic Acid (21). N-Methylamine from the previous synthesis (1.0 mmol) was dissolved in 20 mL of chloroform. A 1.1 mmol sample of diglycolic anhydride was added, and the mixture was stirred under reflux for 2 h. After cooling, the solvent was evaporated. The solid was recrystallized from acetone to give pure acids.

Provenance & Evidence