2-Fluoro-4-iodoaniline → 2,3-difluoro-N-(2-fluoro-4-iodophenyl)-5-(2-methoxyethoxy)-6-nitroaniline

Participants

Role	Name	HCID	Charge
Reactant	2-Fluoro-4-iodoaniline	HCID 185694	—
Reactant	1,2,3-Trifluoro-5-(2-methoxyethoxy)-4-nitrobenzene	HCID 59386372	—
Product	2,3-difluoro-N-(2-fluoro-4-iodophenyl)-5-(2-methoxyethoxy)-6-nitroaniline	HCID 59386301	32%

Reaction Steps

2-Fluoro-4-iodoaniline (1.6 g, 6.8 mmol) and 1,2,3-trifluoro-5-(2-methoxyethoxy)-4-nitrobenzene (1.7 g, 6.8 mmol) were reacted using the condition described in Example 1 (Step A) to form the title compound (1.02 g, 32%); m/z=467 [M−1].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08829052B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-06e36c2b778c4915ac0c3bb1eb1c3223
Source note	uspto-grants-2014_09