HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → (R)-2-(5-hydroxy-indol-1-yl)-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 8-Chloro-5-(3-isothiocyanato-phenyl)-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol | HCID 9819535 | — |
| Solvent | Water | HCID 962 | — |
| Product | (R)-2-(5-hydroxy-indol-1-yl)-propionic acid methyl ester | HCID 57845515 | — |
Reaction Steps
Reverse Phase HPLC conditions: Column: YMC-Pack ProC18 (AS-300), 50×4.6 mm (I.D.), S-5 μm, 12 nm (No. 040506614); Mobile Phase: A: 0.1% TFA in Water; B: 0.1% TFA in Acetonitrile; Gradient: 90-5% A (10-95% B) in 7 min; Flow rate: 4.0 mL/min; Detector (UV): 220 nm. Retention time of the title compound: 2.54 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592361B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-002b01f1cf5d4f8faf3d0b10b25340a9 |
| Source note | uspto-grants-2009_09 |