Cesium carbonate → 1-[3-(benzyloxy)benzyl]-2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1h-imidazole

Participants

Reaction Steps

To a mixture of the compound of Example 58 (90 mg, 0.45 mmol) and caesium carbonate (244 mg, 0.75 mmol) in 1-methyl-2-pyrrolidinone (1 ml) was added 1-(benzyloxy)-3-(bromomethyl)benzene (139 mg, 0.50 mmol). The reaction mixture was stirred at room temperature for 48 h and then filtered through a Whatman PTFE filter tube (5 μm).

Provenance & Evidence