反应详情

To a mixture of the compound of Example 58 (100 mg, 0.5 mmol) and caesium carbonate (407 mg, 1.25 mmol) in acetone (4 ml) was added iodomethane (78 μl, 1.25 mmol). The reaction mixture was stirred at room temperature, under nitrogen, for 4 h and then concentrated in vacuo. to the residue was added water (10 ml) and the solution was extracted with ethyl acetate (2×10 ml). The combined extracts were dried (MgSO4) and concentrated in vacuo.

1. concentrationconcentrated in vacuo
2. additionto the residue was added water (10 ml)
3. extractionthe solution was extracted with ethyl acetate (2×10 ml)
4. dry with materialThe combined extracts were dried (MgSO4)
5. concentrationconcentrated in vacuo