反应详情

温度

0 °C

Sodium borohydride (0.015 g, 1.6 eq) was added to a stirred solution of N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]acetyl}phenyl)acetamide (0.102 g, 1 eq) in dry DCM (2 mL) cooled to 0° C. under an inert atmosphere. The reaction was warmed to room temperature and stirred for 18 hours. The mixture was diluted with DCM (10 mL) and washed with water (2×10 mL). The organic phase was dried over sodium sulfate and the solvent was removed under reduced pressure. The crude material was purified on SPE cartridge (Silica) using as eluant DCM-methanol (97:3), affording the title compound in 42% yield (0.104 g).

1. temperatureThe reaction was warmed to room temperature
2. washwashed with water (2×10 mL)
3. dry with materialThe organic phase was dried over sodium sulfate
4. customthe solvent was removed under reduced pressure
5. customThe crude material was purified on SPE cartridge (Silica)