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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 734559Generated: October 25, 2026

3-Fluorophthalic anhydride → 4-fluoro-2-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1H-isoindole-1,3(2H)-dione

https://huagongshe.com/reaction/734559

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluorophthalic anhydrideHCID 69551—
Reactant3-(2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}anilineHCID 49852105—
Product4-fluoro-2-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1H-isoindole-1,3(2H)-dioneHCID 68427408—

Reaction Steps

Prepared from 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D6) and 4-fluoro-2-benzofuran-1,3-dione according to Method I.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07592346B2
Source datasetuspto-grants-2009_09
ORD IDord-0a25832932bd4c4bb6296ba9a4fd0305
Source noteuspto-grants-2009_09